Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/157576807?client_source=feed&format=rss
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Saturday, November 5, 2011
Headache tree is a pain in the brain
Bay laurel swells cranial blood vessels
Web edition : Thursday, November 3rd, 2011
One whiff of a plant known as the headache tree can spur intense, excruciating pain ? and now scientists know why.? An ingredient in the tree sets off a chain of events that eventually amps up blood flow to the brain?s outer membrane.
Other headache triggers, such as chlorine, cigarette smoke and formaldehyde, interact with some of the same cellular machinery, suggesting they all work via the same pain-inducing mechanism.
In the new study, an international group of researchers extracted the plant compound umbellulone from dried bay laurel leaves and then exposed various mouse and rat cells to the compound.? Umbellulone tickles the same cellular detector that responds to painfully cold stimuli and the sinus-clearing scent of wasabi and mustard oil, the researchers report online October 27 in Brain.
Stimulating this chemical detector ultimately triggers the release of a particular protein implicated in migraine headaches, the researchers found. This protein prompts blood vessels to swell, and scientists think this swelling puts pressure on the skull and nerves, causing pain.
The new research is solid, says neuroscientist Peter Goadsby, director of the headache center at the University of California, San Francisco. Other irritants linked to headaches interact with the same chemical detector, and it may be a good target for therapy, Goadsby says.
The scent of the bay laurel tree, Umbellularia californica, had been anecdotally implicated as a headache trigger, but it took a self-experimenting headache-sufferer to bring the plant to the attention of researchers in the Headache Center at the University of Florence. Pierangelo Geppetti, who led the study, heard from a friend about a man who was trimming trees on his property and suddenly experienced a cold sensation in his left nostril and then excruciating pain around his left eye. In his youth, the man had regularly gotten cluster headaches, which are one-sided, intense bouts of exceptional pain that often recur in people who suffer from them.
Unlike a full-bore cluster headache, the man?s symptoms quickly faded, and he forgot about the episode. But a few months later when he was again working with bay laurel, the headache struck again.? This prompted him to experiment, intentionally sniffing the crushed leaves of the tree. The intense pain resumed and not long after, Geppetti heard the headache story from their mutual friend.? Intrigued, he began investigating the chemical compounds that might be responsible.
Found in: Body & Brain and Molecules
Source: http://www.sciencenews.org/view/generic/id/335845/title/Headache_tree_is_a_pain_in_the_brain
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NYU Langone experts present at American College of Rheumatology 2011 Annual Meeting
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Public release date: 4-Nov-2011[ | E-mail |
Share ] Contact: Craig Andrews
craig.andrews@nyumc.org
212-404-3511
NYU Langone Medical Center / New York University School of Medicine
Experts from NYU Langone Medical Center will present new research findings and clinical insight into the treatment of rheumatic and bone diseases in a variety of presentations at the American College of Rheumatology (ACR) 2011 Annual Scientific Meeting in Chicago, November 5-9, 2011.
Press Conferences
Osteoarthritis and Bone Unintended Consequences: Increased Prescription of Narcotic Analgesics for OA in the Elderly is Associated with Increased Falls and Fractures in the Post-Vioxx Era
Lydia Rolita, MD and Bruce N. Cronstein, MD
Monday, November 7 at 8:30AM
Following the removal of Vioxx from the market there was a marked increase in the prescription of narcotic analgesics. Subsequently, the number of falls and fractures among the elderly population with osteoarthritis also went up which was attributed to patients prescribed narcotic analgesics. The findings strongly indicate that recommendations for the treatment of chronic pain be re-evaluated.
Lupus, Gout and Vaccines Favorable Prognosis in a Large, Prospective Multicenter Study of Lupus Pregnancies
Jill P. Buyon, MD
Tuesday, November 8 at 8:30AM
A study of pregnant women with systemic lupus erythematosus found eighty percent (80%) of women had positive outcomes, with adverse outcomes associated with an increase in lupus activity during pregnancy, high titer aPL antibody, and higher levels of uric acid at baseline. This large, prospective study provides reassurances to those patients with stable lupus considering pregnancy and suggests guidelines for those at-risk patients.
Presentations, Demonstrations & Panel Discussion
A Distinctive Oral Microbiome Characterizes Periodontitis in Patients with Early Rheumatoid Arthritis
Jose U. Scher, MD
Tuesday, November 8 at 4:45PM
This presentation investigates the abundance of a unique subgingival oral microbiota in patients with new-onset, never-treated rheumatoid arthritis, compared to those with chronic-established RA and healthy individuals. The study suggests that further identification and characterization of Porphyromonas species as well as other bacteria may help explain the reported link between RA and periodontal disease.
Successes in Rheumatology Comparative Effectiveness Research Registries/Cohorts That Have Made a Difference in Rheumatology
Jeffrey Greenberg, MPH, MD
Saturday, November 5 at 3:00PM
This presentation highlights the value of comparative effectiveness research and how it enables the evaluation and comparison of the health outcomes, risks and benefits of established, commonly used treatments without the expense and limitations of randomized, controlled clinical trials.
ACR State of the Art Lecture Biomarkers in Systemic Lupus Erythematosus: Where Do We Stand?
Jill P. Buyon, MD and Anca D. Askanase, MD
Monday November 7 at 1:00PM
This lecture will provide an understanding of the ongoing efforts to identify and validate biomarkers needed to advance the diagnosis, monitoring and treatment of systemic lupus erythematosus.
Rheumatic Disease Update Paraneoplastic Rheumatic Disorders
Yusef Yazici, MD
Monday, November 7 at 2:30PM
The presentation will look at rheumatologic disorders known to be associated with a variety of malignancies and the challenge clinicians' face in identifying a malignancy that may not be apparent when rheumatic disease first appears.
Leveraging Existing Resources for Your Research Introduction to the Clinical and Translational Science Award
Bruce N. Cronstein, MD
Monday, November 7 at 4:30PM
This session will introduce early career investigators to CTSA research resources and alternatives when a CTSA center is not available.
ACR Clinical Symposia Hyperuricemia and Gout: Mechanisms and Morbidity
Michael H. Pillinger, MD
Tuesday, November 8 at 1:00PM
This discussion offers clinicians an update on recent findings on the pathogenesis and consequences of hyperuricemia and gout, one of the most common forms of inflammatory arthritis in men over the age of 50.
ACR Workshops - Patient Questionnaires to Monitor Status and Document Improvement in Standard Care: Practical Considerations
Theodore Pincus, MD
Tuesday, November 8 at 4:00PM
During this workshop, attendees will learn about the significance of patient questionnaire data in the prognosis of long-term care, how a rheumatology practice can use patient questionnaires to monitor and document patient status, identify incomplete responses to therapies or a need for changes in tight control of inflammation.
###
About NYU Langone Medical Center
NYU Langone Medical Center, a world-class patient-centered integrated academic medical center, is one of the nation's premier centers for excellence in health care, biomedical research, and medical education. Located in the heart of Manhattan, NYU Langone is comprised of three hospitals Tisch Hospital, a 705-bed acute-care tertiary facility, Rusk Institute of Rehabilitation Medicine, the first rehabilitation hospital in the world, with 174 beds and extensive outpatient rehabilitation programs, and the 190-bed Hospital for Joint Diseases, one of only five hospitals in the world dedicated to orthopaedics and rheumatology plus the NYU School of Medicine, one of the nation's preeminent academic institutions. For more information visit www.NYULMC.org.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 4-Nov-2011[ | E-mail |
Share ] Contact: Craig Andrews
craig.andrews@nyumc.org
212-404-3511
NYU Langone Medical Center / New York University School of Medicine
Experts from NYU Langone Medical Center will present new research findings and clinical insight into the treatment of rheumatic and bone diseases in a variety of presentations at the American College of Rheumatology (ACR) 2011 Annual Scientific Meeting in Chicago, November 5-9, 2011.
Press Conferences
Osteoarthritis and Bone Unintended Consequences: Increased Prescription of Narcotic Analgesics for OA in the Elderly is Associated with Increased Falls and Fractures in the Post-Vioxx Era
Lydia Rolita, MD and Bruce N. Cronstein, MD
Monday, November 7 at 8:30AM
Following the removal of Vioxx from the market there was a marked increase in the prescription of narcotic analgesics. Subsequently, the number of falls and fractures among the elderly population with osteoarthritis also went up which was attributed to patients prescribed narcotic analgesics. The findings strongly indicate that recommendations for the treatment of chronic pain be re-evaluated.
Lupus, Gout and Vaccines Favorable Prognosis in a Large, Prospective Multicenter Study of Lupus Pregnancies
Jill P. Buyon, MD
Tuesday, November 8 at 8:30AM
A study of pregnant women with systemic lupus erythematosus found eighty percent (80%) of women had positive outcomes, with adverse outcomes associated with an increase in lupus activity during pregnancy, high titer aPL antibody, and higher levels of uric acid at baseline. This large, prospective study provides reassurances to those patients with stable lupus considering pregnancy and suggests guidelines for those at-risk patients.
Presentations, Demonstrations & Panel Discussion
A Distinctive Oral Microbiome Characterizes Periodontitis in Patients with Early Rheumatoid Arthritis
Jose U. Scher, MD
Tuesday, November 8 at 4:45PM
This presentation investigates the abundance of a unique subgingival oral microbiota in patients with new-onset, never-treated rheumatoid arthritis, compared to those with chronic-established RA and healthy individuals. The study suggests that further identification and characterization of Porphyromonas species as well as other bacteria may help explain the reported link between RA and periodontal disease.
Successes in Rheumatology Comparative Effectiveness Research Registries/Cohorts That Have Made a Difference in Rheumatology
Jeffrey Greenberg, MPH, MD
Saturday, November 5 at 3:00PM
This presentation highlights the value of comparative effectiveness research and how it enables the evaluation and comparison of the health outcomes, risks and benefits of established, commonly used treatments without the expense and limitations of randomized, controlled clinical trials.
ACR State of the Art Lecture Biomarkers in Systemic Lupus Erythematosus: Where Do We Stand?
Jill P. Buyon, MD and Anca D. Askanase, MD
Monday November 7 at 1:00PM
This lecture will provide an understanding of the ongoing efforts to identify and validate biomarkers needed to advance the diagnosis, monitoring and treatment of systemic lupus erythematosus.
Rheumatic Disease Update Paraneoplastic Rheumatic Disorders
Yusef Yazici, MD
Monday, November 7 at 2:30PM
The presentation will look at rheumatologic disorders known to be associated with a variety of malignancies and the challenge clinicians' face in identifying a malignancy that may not be apparent when rheumatic disease first appears.
Leveraging Existing Resources for Your Research Introduction to the Clinical and Translational Science Award
Bruce N. Cronstein, MD
Monday, November 7 at 4:30PM
This session will introduce early career investigators to CTSA research resources and alternatives when a CTSA center is not available.
ACR Clinical Symposia Hyperuricemia and Gout: Mechanisms and Morbidity
Michael H. Pillinger, MD
Tuesday, November 8 at 1:00PM
This discussion offers clinicians an update on recent findings on the pathogenesis and consequences of hyperuricemia and gout, one of the most common forms of inflammatory arthritis in men over the age of 50.
ACR Workshops - Patient Questionnaires to Monitor Status and Document Improvement in Standard Care: Practical Considerations
Theodore Pincus, MD
Tuesday, November 8 at 4:00PM
During this workshop, attendees will learn about the significance of patient questionnaire data in the prognosis of long-term care, how a rheumatology practice can use patient questionnaires to monitor and document patient status, identify incomplete responses to therapies or a need for changes in tight control of inflammation.
###
About NYU Langone Medical Center
NYU Langone Medical Center, a world-class patient-centered integrated academic medical center, is one of the nation's premier centers for excellence in health care, biomedical research, and medical education. Located in the heart of Manhattan, NYU Langone is comprised of three hospitals Tisch Hospital, a 705-bed acute-care tertiary facility, Rusk Institute of Rehabilitation Medicine, the first rehabilitation hospital in the world, with 174 beds and extensive outpatient rehabilitation programs, and the 190-bed Hospital for Joint Diseases, one of only five hospitals in the world dedicated to orthopaedics and rheumatology plus the NYU School of Medicine, one of the nation's preeminent academic institutions. For more information visit www.NYULMC.org.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2011-11/nlmc-nle110411.php
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Friday, November 4, 2011
14 Mexican soldiers sentenced in killing of 5 (AP)
MEXICO CITY ? Mexico's military says 14 soldiers have been convicted and sentenced to prison in the fatal shooting of two women and three children whose vehicle failed to stop at an army checkpoint in 2007.
The Defense Department says a commanding officer received a 40-year sentence in a court martial and another officer received 38 years. A judge gave 12 enlisted soldiers 16-year sentences.
Two soldiers were acquitted.
A military announcement Thursday says the verdicts and sentences were handed down last week.
The case was among the first of suspected abuse by soldiers deployed by President Felipe Calderon when he launched an offensive by federal security forces against drug cartels in late 2006.
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Gigya Launches Platform To Give Businesses Access To Users? Complete Social Identities
Many companies have begun to realize that social is not just a new channel or a new fad, it's a new way of doing business. But learning the ropes, how to use social networks and social channels, and optimize and tailor social features for one's business, is easier said than done. This is where Gigya enters the equation. The startup offers a SaaS technology (or a social CRM platform, if you will) to help businesses make their websites social, integrating their online appendages with Facebook, Twitter, LinkedIn, etc. and consolidating the best social features and widgets into one solution. While the startup has made a play into social commerce with widgets to integrate e-Commerce platforms with social networks, etc., Gigya is today announcing the launch of an important (and perhaps somewhat intimidating) new technology that has big data implications. Social data implications, of course. The tech has been dubbed the "Identity Management Platform", and essentially, it enables businesses to better manage user data by providing them with complete, permission-based access to a user's social, profile, and behavior data culled from activity on their websites.Source: http://feedproxy.google.com/~r/Techcrunch/~3/Qd4_6p5xJJw/
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Braugher back on TV legal turf in `Law & Order' (AP)
LOS ANGELES ? Andre Braugher says he's glad to back in the TV legal arena with a guest appearance on "Law & Order: Special Victims Unit."
Braugher played a police detective on the 1990s series "Homicide: Life on the Street" and recently starred as a car lot manager on TNT's "Men of a Certain Age." On Wednesday night's episode of the NBC drama, Braugher plays a powerful defense attorney whose client is accused of raping a music student.
The actor said Wednesday that he enjoyed his lighter role on "Men of a Certain Age," but he relishes "meaty" dramatic parts. On "Special Victims Unit," Braugher said, his character gives prosecutors and New York police "a run for their money" as he defends his impoverished client.
The episode airs 10 p.m. EST on NBC.
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Thursday, November 3, 2011
Analysis: Putin invokes history's lions for return to Kremlin (Reuters)
MOSCOW (Reuters) ? Vladimir Putin has an answer for Russians worried that his return to the presidency next year will usher in an era of stagnation: study the careers of Franklin D. Roosevelt or Charles de Gaulle.
Putin could be president until 2024 if he wins the maximum two successive terms and by then would have ruled for almost a quarter of a century.
His decision to reclaim the presidency has brought frequent comparisons with Communist leader Leonid Brezhnev, whose 18-year rule of the Soviet Union until his death in 1982 is widely seen as an era of political and economic stagnation.
But Putin, who has remained Russia's paramount leader even as prime minister since 2008, prefers to hold up the examples of long-serving Western leaders to justify his return to the Kremlin, which is all but certain in next March's election.
The former KGB spy's history lessons also give a sense of how he views himself and could provide clues about what his next presidency will hold.
Asked about his decision to return to the post he held for eight years until 2008, Putin corrected an interviewer who referred to Roosevelt, the longest-serving U.S. president.
"Yes, Roosevelt was elected three times," said Konstantin Ernst, the head of the Pervyi Kanal (First Channel).
"No," Putin, 59, snapped back, wagging his finger at Ernst. "Four times."
Roosevelt won elections in 1932, 1936, 1940 and 1944, and died in office in 1945, months after the Yalta Conference where he, Soviet leader Josef Stalin and British Prime Minister Winston Churchill carved up Europe at the end of World War Two.
"He ruled the country in the toughest years of economic depression and in World War Two and was elected four times because he was effective," said Putin, who won presidential elections in 2000 and 2004.
After praising Roosevelt, Putin went on to list other long-serving leaders including Helmut Kohl, who was German chancellor for 16 years. He also said he liked de Gaulle, France's president from 1959 to 1969.
WESTERN STATESMEN
Like Putin, Roosevelt, De Gaulle and Kohl rose to power in tumultuous times but used iron will and considerable popularity to gain almost complete dominance.
Styled by his ruling party as Russia's "national leader", Putin says his biggest achievement is to have saved Russia from collapse after the chaos and humiliation that accompanied the fall of the Soviet Union in 1991.
Putin, and some of the people who own chunks of the world's biggest energy producer, believe he is a ruler who can ensure stability, at least for now.
"He thinks of himself as a national leader," said Nikolai Petrov, a political analyst at the Carnegie Moscow Center.
Heroes of their time to supporters, Roosevelt, De Gaulle and Kohl forged fiercely independent foreign policies but, like Putin, were criticized for accruing too much power.
Opponents say Russia's stability is a mirage because Putin's decision to stay in power makes a brittle and atrophied political system too dependent on one man.
By focusing on Western leaders, Putin is also underscoring to Russian voters his own image as the stout defender of the country's interests in the face of what is often portrayed as Western hypocrisy.
"By invoking de Gaulle and Roosevelt, Putin hints that foreign criticism of him is based on double standards, and presents himself as the country's defender, willing to stand up to hypocritical foreigners who are unfair to Russians," said David Woodruff, senior lecturer in comparative politics at the London School of Economics and Political Science.
For the leaders of the United States, China and Europe, the message is clear: Putin will accept no lecturing but he also wants to be accepted at the top table of world politics.
Even at face value, there may be other parallels.
De Gaulle put down dissent in Syria, Lebanon and Algeria. Under Putin, Russia has been accused of human rights abuses in Chechnya and other republics of the rebellious North Caucasus.
Kohl was criticized for turning a blind eye to party corruption. Putin's ruling United Russia party has been branded "a party of swindlers and thieves" by opponents.
Roosevelt's record stay in the White House prompted Congress to pass the 22nd Amendment to the U.S. Constitution which prevents presidents from serving more than two terms.
PUTIN'S HEROES
Putin also admires Lee Kuan Yew, the founding father of modern Singapore. Such is his regard that some of his closest allies have taken up reading Lee's books. Lee led Singapore for more than 31 years until 1990 but remained senior minister and then minister mentor until May this year.
Putin's use of bumper oil revenues during his first presidency to boost living standards and cement his rule while other economic problems went unsolved has drawn analogies with Soviet leaders, in particular Brezhnev, under whom economic decline was masked by strong the income from oil sales.
"The analogy with Brezhnev is being made... all such analogies are lame and senseless because we live in a different country, a different world," said President Dmitry Medvedev, who was swept into the Kremlin in 2008 to get round a constitutional ban on his mentor Putin serving a third successive term.
Putin has remained the more powerful of the two men in their power-sharing arrangement know as the ruling tandem.
For such an overtly patriotic Russian leader, Putin has made few references to tsars and Communist Party general secretaries, all of whom ruled large empires.
Among the tsars, Putin has preferred comparisons with Peter the Great, a ruthless leader who built Putin's home town of St Petersburg and laid the foundations of the Russian empire.
"Putin reads all the time, mostly about the history of Russia," his spokesman, Dmitry Peskov, said. "He reads memoirs, the memoirs of Russian historical state figures."
Opinion polls show Russians' most popular historical figures are writer and poet Alexander Pushkin, Peter the Great, Josef Stalin, Soviet state founder Vladimir Lenin and Putin.
For Russians, they outrank Jesus Christ, Alexander the Great or scientist Isaac Newton.
But Peskov said Putin had a keen interest in Tsarist Prime Minister Pyotr Stolypin and Russian Orthodox philosopher Ivan Ilyin, who said Russia should plot an independent course between dictatorship and democracy.
Putin has made no secret of his respect for Stolypin, who crushed dissent but also introduced land reform as prime minister from 1906 to 1911 under Czar Nicholas II.
Putin said in July that a statue of Stolypin should be placed outside the Russian government's headquarters in Moscow.
"A true patriot and a wise politician, he understood that both radicalism of all sorts as well as stagnation, a lack of reforms, were equally dangerous for the country," Putin said.
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